How are memories stored and retrieved? With Profs. Karl Deisseroth, Priya Rajasethupathy and colleagues at Stanford University, I developed computational tools to answer this question.
Research Projects
Stanford University
Hub neurons in memory retrieval
We found that information is stored as a small-world network, and discovered “hub neurons” that are preferentially recruited during memory retrieval. The work was published in Nature with me as co-first author.
Fluorescence extracted from in-vivo two-photon images of live, behaving mice.Highly connected “hub” neurons from imaging the hippocampus of mice in various contexts.
Rajasethupathy, P.*, Sankaran, S.*, Marshel, J.H.*, Kim, C.K., Ferenczi, E., Lee, S.Y., Berndt, A., Ramakrishnan, C., Jaffe, A., Lo, M., Liston, C. and Deisseroth, K. Projections from neocortex mediate top-down control of memory retrieval. Nature 526, 653–659, 2015. (*equal contribution) [paper]
Tomer, R., Lovett-Barron, M., Kauvar, I., Andalman, A., Burns, V.M., Sankaran, S., Grosenick, L., Broxton, M., Yang, S. and Deisseroth, K. SPED light sheet microscopy: fast mapping of biological system structure and function. Cell 163(7), 1796–1806, 2015.
